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1. (WO2018015303) SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/015303 International Application No.: PCT/EP2017/067881
Publication Date: 25.01.2018 International Filing Date: 14.07.2017
IPC:
C12N 9/58 (2006.01) ,C12P 7/06 (2006.01) ,C12P 7/10 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
58
derived from fungi
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
04
acyclic
06
Ethanol, i.e. non-beverage
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
04
acyclic
06
Ethanol, i.e. non-beverage
08
produced as by-product or from waste or cellulosic material substrate
10
substrate containing cellulosic material
Applicants: NOVOZYMES A/S[DK/DK]; Krogshoejvej 36 2880 Bagsvaerd, DK
Inventors: KLITGAARD, Dorte, M, K.; DK
PACHE, Roland, Alexander; DK
GUDMAND, Martin; DK
SANDSTRÖM, Anders, G.; DK
Priority Data:
16180498.421.07.2016EP
16195087.821.10.2016EP
Title (EN) SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
(FR) VARIANTS DE SÉRINE PROTÉASE ET POLYNUCLÉOTIDES LES CODANT
Abstract:
(EN) The present invention relates to serine protease variants,having improved properties compared to the parent protease, in particular variants of a serine protease derived from a strain of Meripilus giganteus belonging to the S53 family. The varinats according to the invention have in particular increased stability, e.g., increased thermo-stability, increased specific activity, and/or increased expression levels, compared to the parent protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
(FR) La présente invention concerne des variants de sérine protéase ayant des propriétés supérieures par rapport à la protéase mère, en particulier des variants d'une sérine protéase dérivée d'une souche de Meripilus giganteus appartenant à la famille S53. Les variants selon l'invention présentent en particulier une plus grande stabilité, par exemple une plus grande stabilité thermique, une plus grande activité spécifique et/ou des niveaux d'expression accrus, par rapport à la protéase mère. La présente invention concerne également des polynucléotides codant les variants ; des constructions d'acides nucléiques, des vecteurs et des cellules hôtes comprenant les polynucléotides ; ainsi que des procédés d'utilisation des variants.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)