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|1. (WO2018014841) SELF-ASSEMBLED COLLAGEN AND PREPARATION METHOD THEREFOR|
|Applicants:||SOUTH CHINA INSTITUTE OF BIOMEDICINE
|Title:||SELF-ASSEMBLED COLLAGEN AND PREPARATION METHOD THEREFOR|
A self-assembled collagen and a preparation method therefor. The preparation method for the self-assembled collagen comprises the following steps: utilizing trypsin and papain in an enzymatic treatment of an animal-derived collagen so as to produce a hydrolysate containing small peptides; performing an ultrafiltration treatment on the hydrolysate so as to produce a collagen peptide solution; and mixing the collagen peptide solution with acetic acid and then performing a dialysis treatment so as to produce the self-assembled collagen, where the dialysis treatment employs a phosphate buffer as the dialysate. The method employs specific proteases for hydrolysis of collagen, not only produces the collagen peptide solution of low molecular weight, but also produces a specific “sticky end” at the distal end of the peptide, and forms, by means of self-assembly, a collagen fiber providing improved organ supporting and tissue protecting effects in the body.