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1. (WO2018014841) SELF-ASSEMBLED COLLAGEN AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2018/014841    International Application No.:    PCT/CN2017/093484
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Thu Jul 20 01:59:59 CEST 2017
IPC: C07K 1/12
C07K 1/34
C07K 1/36
C12P 21/00
C12P 21/06
C07K 2/00
Applicants: SOUTH CHINA INSTITUTE OF BIOMEDICINE
华南生物医药研究院
Inventors: PEI, Xuetao
裴雪涛
NAN, Xue
南雪
YOU, Zijuan
游子娟
SHAN, Ziyun
单紫筠
WEI, Hong
魏红
YAO, Hailei
姚海雷
JIA, Xiyuan
贾茜媛
LONG, Dongying
龙冬莹
Title: SELF-ASSEMBLED COLLAGEN AND PREPARATION METHOD THEREFOR
Abstract:
A self-assembled collagen and a preparation method therefor. The preparation method for the self-assembled collagen comprises the following steps: utilizing trypsin and papain in an enzymatic treatment of an animal-derived collagen so as to produce a hydrolysate containing small peptides; performing an ultrafiltration treatment on the hydrolysate so as to produce a collagen peptide solution; and mixing the collagen peptide solution with acetic acid and then performing a dialysis treatment so as to produce the self-assembled collagen, where the dialysis treatment employs a phosphate buffer as the dialysate. The method employs specific proteases for hydrolysis of collagen, not only produces the collagen peptide solution of low molecular weight, but also produces a specific “sticky end” at the distal end of the peptide, and forms, by means of self-assembly, a collagen fiber providing improved organ supporting and tissue protecting effects in the body.