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1. (WO2018014384) TCR-/PD-1- DOUBLE NEGATIVE T-CELL AND CONSTRUCTION METHOD THEREOF
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Pub. No.: WO/2018/014384 International Application No.: PCT/CN2016/094617
Publication Date: 25.01.2018 International Filing Date: 11.08.2016
IPC:
C12N 15/113 (2010.01) ,C12N 15/85 (2006.01) ,C12N 5/10 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/12 (2006.01) ,A61P 31/18 (2006.01) ,A61P 31/20 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
Applicants:
广东华南疫苗股份有限公司 SOUTH CHINA VACCINE CORPORATION LIMITED [CN/CN]; 中国广东省广州市 科学城揽月路3号国际企业孵化器F栋715 Room 715, Building F, International Business Incubator, No. 3, Lanyue Road, Science City Guangzhou, Guangdong 510663, CN
Inventors:
周超 ZHOU, Chao; CN
安鸿 AN, Hong; CN
卢有德 LU, Youde; CN
周玲 ZHOU, Ling; CN
巫春红 WU, Chunhong; CN
彭涛 PENG, Tao; CN
尹海滨 YIN, Haibin Michael; CN
Agent:
广州嘉权专利商标事务所有限公司 JIAQUAN IP LAW FIRM; 中国广东省广州市 天河区黄埔大道西100号富力盈泰广场A栋910张萍 Zhang, Ping No.910, Building A, Winner Plaza No.100 West Huangpu Avenue, Tianhe District Guangzhou, Guangdong 510627, CN
Priority Data:
201610570655.118.07.2016CN
Title (EN) TCR-/PD-1- DOUBLE NEGATIVE T-CELL AND CONSTRUCTION METHOD THEREOF
(FR) LYMPHOCYTE T DOUBLEMENT NÉGATIF EN TCR-/PD-1- ET PROCÉDÉ POUR SA CONSTRUCTION
(ZH) 一种TCR-/PD-1-双阴性T细胞及其构建方法
Abstract:
(EN) Disclosed is a TCR-/PD-1- double negative T-cell and a construction method thereof. Isolated peripheral blood mononuclear cells are activated into T-cells, TCR and PD-1 are knocked out by means of CRISPR/Cas9 gene editing technology, and TCR-/PD-1- double negative T-cells are sorted out by means of magnetic beads.
(FR) L'invention concerne un lymphocyte T doublement négatif en TCR-/PD-1- et un procédé pour sa construction. Des cellules mononucléaires isolées du sang périphérique sont activées en lymphocytes T, TCR et PD-1 sont inactivés au moyen de la technologie d'édition génique CRISPR/Cas9 et des lymphocytes T doublement négatifs en TCR-/PD-1- sont triés au moyen de billes magnétiques.
(ZH) 一种TCR -/PD-1 -双阴性T细胞及其构建方法。将分离的外周血单核细胞激活成T细胞,通过CRISPR/Cas9基因编辑技术敲除TCR和PD-1,并通过磁珠分选出TCR -/PD-1 -双阴性T细胞。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)