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1. (WO2018014260) MULTISPECIFIC ANTIGEN BINDING PROTEINS AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/014260    International Application No.:    PCT/CN2016/090703
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Thu Jul 21 01:59:59 CEST 2016
IPC: C07K 16/46
C07K 16/18
C07K 16/28
C07K 16/30
C07K 16/24
A61K 39/395
A61P 35/00
A61P 37/00
Applicants: NANJING LEGEND BIOTECH CO., LTD.
Inventors: CHOU, Chuan-Chu
ZHANG, Yafeng
WU, Shu
LIU, Zhenyu
LI, Zhongdao
ZHANG, Fangliang
Title: MULTISPECIFIC ANTIGEN BINDING PROTEINS AND METHODS OF USE THEREOF
Abstract:
Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.