Search International and National Patent Collections

1. (WO2018014068) ATTENUATED TYPE I IFN CD47 COMBINATION THERAPY

Pub. No.:    WO/2018/014068    International Application No.:    PCT/AU2017/000151
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Thu Jul 20 01:59:59 CEST 2017
IPC: A61K 38/21
A61K 39/395
C07K 16/30
A61P 39/00
Applicants: TEVA PHARMACEUTICALS AUSTRALIA PTY LTD
Inventors: POGUE, Sarah Lee
WILSON, David Scofield Jr.
TAURA, Tetsuya
Title: ATTENUATED TYPE I IFN CD47 COMBINATION THERAPY
Abstract:
The present invention provides a combination therapy for treating a tumor in a subject. The combination therapy comprises administration of (i) an antibody which binds to a cell surface-associated antigen expressed on the tumor cell, and (ii) a polypeptide construct comprising an attenuated Type I interferon (IFN) linked to an anti-CD47 antibody. The present invention also provides a polypeptide construct comprising an attenuated Type I interferon (IFN) linked to an anti-CD47 antibody.