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1. (WO2018013963) DNA METHYLATION SIGNATURES ASSOCIATED WITH CHILDHOOD TRAUMA AND METHODS INVOLVING SAME

Pub. No.:    WO/2018/013963    International Application No.:    PCT/US2017/042201
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Sat Jul 15 01:59:59 CEST 2017
IPC: C12N 5/07
C12N 15/11
C12Q 1/68
Applicants: STC.UNM
BEARER, Elaine, L.
Inventors: BEARER, Elaine, L.
Title: DNA METHYLATION SIGNATURES ASSOCIATED WITH CHILDHOOD TRAUMA AND METHODS INVOLVING SAME
Abstract:
A method includes obtaining a biological sample from an individual, extracting DNA from cells in the sample, measuring the degree of methylation of the extracted DNA at one or more specified loci, and identifying if at least one locus exhibits an alteration in methylation or a degree of methylation that is outside of a normal limit. The method may further include determining whether an individual was exposed to abuse and/or trauma. In some cases, the method further includes treating the individual with a therapy effective to reverse the differential methylation of the DNA.