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1. (WO2018013957) HYBRID FORMULATION OF RESPONSIVE POLYMERIC NANOCARRIERS FOR THERAPEUTIC AND DIAGNOSTIC DELIVERY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/013957    International Application No.:    PCT/US2017/042188
Publication Date: 18.01.2018 International Filing Date: 14.07.2017
IPC:
A61K 41/00 (2006.01), A61K 47/50 (2017.01), A61K 48/00 (2006.01), C12N 15/113 (2010.01)
Applicants: GRECO, Chad [US/US]; (US).
EPPS, Thomas, III [US/US]; (US).
SULLIVAN, Millicent [US/US]; (US)
Inventors: GRECO, Chad; (US).
EPPS, Thomas, III; (US).
SULLIVAN, Millicent; (US)
Agent: ZHONG, Ling; (US).
RATNERPRESTIA; Ratnerprestia 2200 Renaissance Blvd. Suite 350 King Of Prussia, PA 19406 (US)
Priority Data:
62/362,085 14.07.2016 US
Title (EN) HYBRID FORMULATION OF RESPONSIVE POLYMERIC NANOCARRIERS FOR THERAPEUTIC AND DIAGNOSTIC DELIVERY
(FR) FORMULATION HYBRIDE DE NANOTRANSPORTEURS POLYMÉRIQUES RÉACTIFS, POUR UNE ADMINISTRATION THÉRAPEUTIQUE ET DIAGNOSTIQUE
Abstract: front page image
(EN)The present invention provides a nanocomplex comprising at least one agent and a nanocarrier. The agent is bound to the nanocarrier. The nanocarrier comprises at least one cationic polymer responsive to a stimulus, at least one anionic polymer and at least one lipid. The agent is capable of being released from the nanocarrier upon exposure to the stimulus. The released agent is active. The nanocomplex may be used to deliver the agent into cells, in which the agent may be released from the nanocarrier upon exposure of the cells to the stimulus.
(FR)La présente invention concerne un nanocomplexe comprenant au moins un agent et un nanotransporteur. L'agent est lié au nanotransporteur. Le nanotransporteur comprend au moins un polymère cationique capable de réagir à un stimulus, au moins un polymère anionique, et au moins un lipide. L'agent peut être libéré du nanotransporteur lors d'une exposition au stimulus. L'agent libéré est actif. Le nanocomplexe peut être utilisé pour faire parvenir l'agent à l'intérieur des cellules, l'agent pouvant être libéré par le nanotransporteur lors de l'exposition des cellules au stimulus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)