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1. (WO2018013951) TARGETING ADENOSINE A2A RECEPTORS FOR THE TREATMENT OF LEVODOPA-INDUCED DYSKINESIAS

Pub. No.:    WO/2018/013951    International Application No.:    PCT/US2017/042178
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Sat Jul 15 01:59:59 CEST 2017
IPC: A61K 31/198
A61P 25/14
A61P 25/16
Applicants: NORTHWESTERN UNIVERSITY
Inventors: SURMEIER, Dalton James, JR.
SHEN, Weixing
Title: TARGETING ADENOSINE A2A RECEPTORS FOR THE TREATMENT OF LEVODOPA-INDUCED DYSKINESIAS
Abstract:
Provided herein are compositions and methods for the treatment and of neurodegenerative disorders and levodopa-induced dyskinesias. In particular, A2a receptor antagonists are provided, as well as methods for the use of A2a receptor antagonists in the treatment of neurodegenerative disorders (e.g., Parkinsons disease) and the treatment and/or prevention levodopa-induced dyskinesias associated with such treatment.