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1. (WO2018013948) MITOCHONDRIA-TARGETING FLUORESCENT POTASSIUM+ SENSOR AND METHOD OF MAKING THE SAME

Pub. No.:    WO/2018/013948    International Application No.:    PCT/US2017/042174
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Sat Jul 15 01:59:59 CEST 2017
IPC: A61K 31/407
C07D 498/02
C07D 498/08
Applicants: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Inventors: KONG, Xiangxing
TIAN, Yanqing
SU, Fengyu
ZHANG, Liqiang
MELDRUM, Deirdre
Title: MITOCHONDRIA-TARGETING FLUORESCENT POTASSIUM+ SENSOR AND METHOD OF MAKING THE SAME
Abstract:
Mitochondria-targeting potassium sensors and method(s) for making such sensors. The sensor shows a response to potassium and displays a 130-fold dynamic range of fluorescence intensity and high brightness. The sensors response to potassium concentrations was demonstrated to be unaffected by cellular pH value and/or concentrations of other ions. The sensors can be used for monitoring the mitochondrial potassium efflux/influx.