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1. (WO2018013924) SYNTHETIC NANOPARTICLES FOR DELIVERY OF IMMUNOMODULATORY COMPOUNDS

Pub. No.:    WO/2018/013924    International Application No.:    PCT/US2017/042139
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Sat Jul 15 01:59:59 CEST 2017
IPC: C07K 14/00
A61K 47/54
A61K 47/69
A61K 47/64
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors: IRVINE, Darrell, J.
DANE, Eric
Title: SYNTHETIC NANOPARTICLES FOR DELIVERY OF IMMUNOMODULATORY COMPOUNDS
Abstract:
The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of cancers and infectious diseases.