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1. (WO2018013915) TREATMENT OF ISCHEMIA REPERFUSION INJURY USING ALPHA-2 MACROGLOBULIN

Pub. No.:    WO/2018/013915    International Application No.:    PCT/US2017/042125
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Sat Jul 15 01:59:59 CEST 2017
IPC: A61K 47/48
A61K 47/50
A61K 47/64
A61P 7/02
A61P 9/10
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY
Inventors: ABBATE, Antonio
TOLDO, Stefano
Title: TREATMENT OF ISCHEMIA REPERFUSION INJURY USING ALPHA-2 MACROGLOBULIN
Abstract:
Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.