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1. (WO2018013775) GRANULIN COMPOSITIONS AND USES RELATED THERETO
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/013775    International Application No.:    PCT/US2017/041879
Publication Date: 18.01.2018 International Filing Date: 13.07.2017
IPC:
A61K 48/00 (2006.01), A61K 9/00 (2006.01), A61K 9/18 (2006.01), C12N 5/00 (2006.01), C07H 21/04 (2006.01)
Applicants: EMORY UNIVERSITY [US/US]; Office of Technology Transfer 1599 Clifton Road NE, 4th Floor Atlanta, Georgia 30322 (US)
Inventors: KUKAR, Thomas; (US)
Agent: MASON, James C.; (US).
FRITTS, Laura; (US).
ISAACS, Randi; (US).
SHERER, Todd; (US)
Priority Data:
62/362,367 14.07.2016 US
Title (EN) GRANULIN COMPOSITIONS AND USES RELATED THERETO
(FR) COMPOSITIONS DE GRANULINES ET UTILISATIONS ASSOCIÉES
Abstract: front page image
(EN)This disclosure relates to purified and recombinant granulins, fusions, or variants and vectors encoding the same. In certain embodiments, this disclosure relates to uses of these granulins or vectors, alone or in combination, in the treatment or prevention of diseases or conditions associated with lysosomal defects such as frontotemporal dementia and Alzheimer's disease.
(FR)L'invention concerne des granulines purifiées et recombinantes, des fusions ou des variants et des vecteurs codant pour de telles granulines. Selon certains modes de réalisation, la présente invention concerne des utilisations de ces granulines ou de ces vecteurs, seul(e)s ou en combinaison, dans le traitement ou la prévention de maladies ou d'états associés à des anomalies lysosomales telles que la démence fronto-temporale et la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)