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Pub. No.:    WO/2018/013686    International Application No.:    PCT/US2017/041709
Publication Date: 18.01.2018 International Filing Date: 12.07.2017
C07D 209/14 (2006.01), A61K 31/4045 (2006.01)
Applicants: CONCERT PHARMACEUTICALS, INC. [US/US]; 99 Hayden Avenue, Suite 500 Lexington, MA 02421 (US)
Inventors: SILVERMAN, I., Robert; (US)
Agent: ABELLEIRA, Susan, M.; (US).
CHOI, Philip, S.; (US).
SILVERMAN, I., Robert; (US).
BLOUNT, Jennifer, V.; (US).
AKHIEZER, Alexander; (US)
Priority Data:
62/361,316 12.07.2016 US
Abstract: front page image
(EN)This invention relates to indol-3-yl)ethyl]-3-(tetrafluoropropoxy)benzylamines of Formula (I), wherein each variable is defined herein, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an antagonist of the serotonin-6 (5-HT6) receptor, such as Alzheimer's Disease.
(FR)L'invention concerne des indol-3-yl) éthyl]-3-(tétrafluoropropoxy) benzylamines de formule (I), où chaque variable est définie dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des compositions contenant un composé de cette invention et l'utilisation de ces compositions dans des procédés de traitement de maladies et de états avantageusement traités par l'administration d'un antagoniste du récepteur sérotonine-6 (5-HT6), tel que la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)