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1. (WO2018013615) C7, C12, AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE

Pub. No.:    WO/2018/013615    International Application No.:    PCT/US2017/041605
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Wed Jul 12 01:59:59 CEST 2017
IPC: C07J 1/00
C07J 7/00
C07J 43/00
A61K 31/57
A61K 31/58
A61P 25/00
Applicants: SAGE THERAPEUTICS, INC.
Inventors: ROBICHAUD, Albert, J.
MARTINEZ BOTELLA, Gabriel
HARRISON, Boyd, L.
SALITURO, Francesco, G.
GRIFFIN, Andrew
BLANCO-PILLADO, Maria Jesus
Title: C7, C12, AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
Abstract:
Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b, R12, R16, R17, R19, and ----- are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.