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|1. (WO2018013615) C7, C12, AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE|
|Applicants:||SAGE THERAPEUTICS, INC.
|Inventors:||ROBICHAUD, Albert, J.
MARTINEZ BOTELLA, Gabriel
HARRISON, Boyd, L.
SALITURO, Francesco, G.
BLANCO-PILLADO, Maria Jesus
|Title:||C7, C12, AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE|
Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b, R12, R16, R17, R19, and ----- are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.