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1. (WO2018013606) SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE

Pub. No.:    WO/2018/013606    International Application No.:    PCT/US2017/041590
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Wed Jul 12 01:59:59 CEST 2017
IPC: C12N 1/20
C12N 5/00
Applicants: CALIFORNIA INSTITUTE OF TECHNOLOGY
CITY OF HOPE
Inventors: TAI, Yu-Chong
LIU, Yang
COOK, Colin A.
FONG, Yuman
CHEN, Nanhai G.
Title: SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
Abstract:
A polymer or other substrate optimized for growing cells, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system.