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1. (WO2018011344) METHOD AND MEANS FOR DETECTING THE LEVEL OF TOTAL VEGF-A
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Pub. No.: WO/2018/011344 International Application No.: PCT/EP2017/067707
Publication Date: 18.01.2018 International Filing Date: 13.07.2017
IPC:
G01N 33/74 (2006.01) ,C07K 16/22 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74
involving hormones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
22
against growth factors
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
HOFFMANN-LA ROCHE INC. [US/US]; Great Notch, 150 Clove Road, 8th Floor Little Falls, New Jersey 07424, US (US)
Inventors:
ENGEL, Alfred; DE
KARL, Johann; DE
RABE, Christina; DE
SCHRAEML, Michael; DE
SOUKUPOVA, Monika; DE
STEGMUELLER, Peter; DE
WILD, Norbert; DE
Agent:
WOLTERS, Brit; DE
BURGER, Alexander; DE
EISENMANN, Ulrike; DE
GOEHRING, Frank; DE
HILDEBRANDT, Martin; DE
JENNI, Wolfgang; DE
MERTES, Maria; DE
MISERA, Simon; DE
NASER, Werner; DE
SKOLAUT, Alexander; DE
HEINEMEYER, Thomas; DE
Priority Data:
16179780.815.07.2016EP
Title (EN) METHOD AND MEANS FOR DETECTING THE LEVEL OF TOTAL VEGF-A
(FR) PROCÉDÉ ET MOYENS DESTINÉS À DÉTECTER LE NIVEAU DE VEGF-A TOTAL
Abstract:
(EN) The present invention relates to a method for measuring the level of VEGF-A in the presence of a VEGF-A antagonist, kits comprising means for detecting VEGF-A in the presence of a VEGF-A antagonist, compositions of matter comprising a first and a second antibody suitable for detecting the level of VEGF-A in the presence of a VEGF-A antagonist, as well as methods of detecting a complex comprising human VEGF-A and a non-human or chimeric protein.
(FR) La présente invention concerne un procédé permettant de mesurer le taux de VEGF-A en présence d'un antagoniste du VEGF-A, des kits comprenant des moyens permettant de détecter le VEGF-A en présence d'un antagoniste du VEGF-A, des compositions de substances comprenant un premier et un second anticorps appropriés pour détecter le taux de VEGF-A en présence d'un antagoniste du VEGF-A, ainsi que des procédés de détection d'un complexe comprenant le VEGF-A humain et une protéine non humaine ou chimérique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)