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1. (WO2018011067) NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/011067 International Application No.: PCT/EP2017/067049
Publication Date: 18.01.2018 International Filing Date: 07.07.2017
Chapter 2 Demand Filed: 09.05.2018
IPC:
C07H 1/00 (2006.01) ,C07H 21/00 (2006.01) ,C12N 9/00 (2006.01)
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED[GB/GB]; 980 Great West Road Brentford Middlesex TW8 9GS, GB
Inventors: CRAMERI, Andreas; GB
HILL, Malcolm Leithhead; GB
LOVELOCK, Sarah Louise; GB
SCHOBER, Markus; GB
TEW, David Graham; GB
THOMAS, Pamela Joan; GB
Agent: HARRISON, Anna; GB
HITCHCOCK, Lucy Rose; GB
Priority Data:
1612011.511.07.2016GB
Title (EN) NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES
(FR) NOUVEAUX PROCÉDÉS DE PRODUCTION D'OLIGONUCLÉOTIDES
Abstract:
(EN) Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy, said processes comprising: a) providing a template oligonucleotide (I) complimentary to the sequence of the product, said template having properties that allow it to be separated from the product; b) providing a pool of oligonucleotides (II); c) contacting (I) and (II) in conditions to allow annealing; d) changing the conditions to separate any impurities, comprising denaturing the annealed template and impurity oligonucleotide strands and separating the impurities; and e) changing the conditions to separate the product, comprising denaturing the annealed template and product oligonucleotide strands and separating the product.
(FR) L'invention concerne de nouveaux procédés de production d'oligonucléotides pouvant être utilisés dans la production d'oligonucléotides modifiés chimiquement, tels que ceux utilisés en thérapie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)