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1. (WO2018010594) APPLICATION OF HYDROXYPROPYL METHYLCELLULOSE AND COMPOSITION COMPRISING THEREOF FOR MANUFACTURING A PHARMACEUTICAL PRODUCT FOR UPPER GASTROINTESTINAL MUCOSA CARE
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Pub. No.:    WO/2018/010594    International Application No.:    PCT/CN2017/092090
Publication Date: 18.01.2018 International Filing Date: 06.07.2017
IPC:
A61K 31/717 (2006.01), A61P 1/02 (2006.01), A61P 1/04 (2006.01)
Applicants: HEFEI JIU YAN MEDICINE TECHNOLOGY DEVELOPMENT CO., LTD [CN/CN]; The Third Floor of The Mei Xin Pharmaceutical, No. 295 Yonghe Road Hefei, Anhui 230000 (CN)
Inventors: GAO, Yu; (CN).
BU, Yunli; (CN)
Agent: CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED; 18th Floor Tower B, CEC Plaza, No. 3 Dan Ling Street, Haidian District Beijing 100080 (CN)
Priority Data:
201610546792.1 12.07.2016 CN
Title (EN) APPLICATION OF HYDROXYPROPYL METHYLCELLULOSE AND COMPOSITION COMPRISING THEREOF FOR MANUFACTURING A PHARMACEUTICAL PRODUCT FOR UPPER GASTROINTESTINAL MUCOSA CARE
(FR) CELLULOSE D’HYDROXYPROPYL MÉTHYLÉTHER ET APPLICATIONS THÉRAPEUTIQUES DE LA COMPOSITION PHARMACEUTIQUE DE PROTECTION DE LA MUQUEUSE GASTRO-INTESTINALE LA CONTENANT
(ZH) 羟丙基甲基纤维素及含有其的组合物在上消化道黏膜护理药物的制备中的应用
Abstract: front page image
(EN)A composition comprising a hydroxypropyl methylcellulose, comprising: 1-28 parts by weight of the hydroxypropyl methylcellulose, and 1,000 parts by weight of purified water. The composition further comprises: 1-10 parts by weight of a sodium carboxymethyl cellulose or a maltodextrin, 30-150 parts by weight of a glycerol, 0.3-20 parts by weight of a stabilizer, and 0.001-0.1 parts by weight of a flavoring. The composition further comprises: 1-90 parts by weight of a sodium bicarbonate, 10-40 parts by weight of a xylitol, 0.1-6 parts by weight of a citric acid, 2-9 parts by weight of a potassium hydroxide, 2-10 parts by weight of phosphoric acid, and 0.1-2 parts by weight of a sodium benzoate. The composition further comprises: 10-40 parts by weight of a polydextrose. The hydroxypropyl methylcellulose and a composition comprising same can generate a thin film in the upper gastrointestinal tract, and have a mucoadhesion property.
(FR)Composition pharmaceutique contenant une cellulose d’hydroxypropyl méthyléther comprenant, exprimées en poids : 1-28 parties de cellulose d’hydroxypropyl méthyléther, 1000 parties d’eau purifiée et comprenant en outre : 1-10 parties de sodium carboxymethylcellulose ou de maltodextrine, 30-150 parties de glycérol, 0,3-20 parties de stabilisateur et 0,001-0,1 partie d’essences. Elle comprend encore : 1-90 parties de bicarbonate de sodium, 10-40 parties de xylitol, 0,1-6 parties d’acide citrique, 2-9 parties d’hydroxide de potassium, 2-10 parties d’acide phosphorique et 0,1-2 parties de benzoate de sodium. Elle comprend par ailleurs 10-40 parties de polydextrose. La cellulose d’hydroxypropyl méthyléther et la composition de protection de la muqueuse gastro-intestinale la contenant sont déposées sur le film de production gastro-intestinal et peuvent y être collées.
(ZH)一种含有羟丙基甲基纤维素的组合物,包括:羟丙基甲基纤维素1~28重量份、纯化水1000重量份;进一步还包括:羧甲基纤维素钠或麦芽糊精1~10重量份、甘油30~150重量份、稳定剂0.3~20重量份、香精0.001~0.1重量份;进一步还包括:碳酸氢钠1~90重量份、木糖醇10~40重量份、柠檬酸0.1~6重量份、氢氧化钾2~9重量份、磷酸2~10重量份、苯甲酸钠0.1~2重量份;进一步还包括:聚葡萄糖10~40重量份。羟丙基甲基纤维素及含有其的组合物在上消化道产生薄膜,并具有粘膜粘附性。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)