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1. (WO2018010571) INJECTABLE PHARMACEUTICAL COMPOSITION OF TECOVIRIMAT AND PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/010571    International Application No.:    PCT/CN2017/091650
Publication Date: 18.01.2018 International Filing Date: 04.07.2017
Chapter 2 Demand Filed:    16.03.2018    
IPC:
A61K 31/403 (2006.01), A61K 47/18 (2006.01), A61K 9/08 (2006.01), A61K 9/19 (2006.01), A61P 31/20 (2006.01)
Applicants: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA [CN/CN]; No.27, Taiping Road, Haidian District Beijing 100850 (CN)
Inventors: ZHONG, Wu; (CN).
YANG, Meiyan; (CN).
GONG, Wei; (CN).
WANG, Yuli; (CN).
GAO, Chunsheng; (CN).
ZHOU, Xinbo; (CN).
LI, Song; (CN)
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street, Xicheng District Beijing 100037 (CN)
Priority Data:
201610559479.1 15.07.2016 CN
Title (EN) INJECTABLE PHARMACEUTICAL COMPOSITION OF TECOVIRIMAT AND PREPARATION METHOD THEREOF
(FR) COMPOSITION PHARMACEUTIQUE DE TECOVIRIMAT À ADMINISTRATION PAR VOIE INTRAVEINEUSE ET SA MÉTHODE DE PRÉPARATION
(ZH) 一种特考韦瑞注射用药物组合物及其制备方法
Abstract: front page image
(EN)Disclosed is an injectable pharmaceutical composition of tecovirimat, comprising an active ingredient tecovirimat, a cyclodextrin and an additive. Also disclosed is a method for preparing the pharmaceutical composition. The composition improves the solubility of the tecovirimat in water by using the combination of the cyclodextrin and meglumine, compared to the use of cyclodextrin alone or meglumine alone.
(FR)L’invention concerne une composition pharmaceutique de tecovirimat à administration par voie intraveineuse renfermant comme principe actif un tecovirimat, une cyclodextrine et un complément. L'invention concerne en outre une méthode de préparation de cette composition pharmaceutique et ses applications. Cette composition pharmaceutique permet d’augmenter l’hydrosolubilité du tecovirimat par rapport à une composition ne contenant qu’une cyclodextrine ou qu’une meglumine, et ce, grâce à la combinaison de la cyclodextrine et de la meglumine.
(ZH)本发明公开了一种特考韦瑞注射用药物组合物,含有活性成分特考韦瑞、环糊精和附加剂。还公开了该药物组合物的制备方法。该组合物通过联合使用环糊精和葡甲胺,比单独使用环糊精或单独使用葡甲胺,提高了特考韦瑞的水中溶解度。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)