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1. (WO2018010570) ORAL PHARMACEUTICAL COMPOSITION OF TECOVIRIMAT AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2018/010570    International Application No.:    PCT/CN2017/091648
Publication Date: Fri Jan 19 00:59:59 CET 2018 International Filing Date: Wed Jul 05 01:59:59 CEST 2017
IPC: A61K 31/403
A61K 47/18
A61K 9/08
A61P 31/20
Applicants: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA
中国人民解放军军事医学科学院毒物药物研究所
Inventors: ZHONG, Wu
钟武
YANG, Meiyan
杨美燕
GONG, Wei
龚伟
WANG, Yuli
王玉丽
GAO, Chunsheng
高春生
ZHOU, Xinbo
周辛波
LI, Song
李松
Title: ORAL PHARMACEUTICAL COMPOSITION OF TECOVIRIMAT AND PREPARATION METHOD THEREFOR
Abstract:
Disclosed is a pharmaceutical composition, comprising an active ingredient tecovirimat, a cyclodextrin and an additive, and optionally, a pharmaceutically acceptable excipient. Also disclosed is a method for preparing the pharmaceutical composition. The composition improves the solubility of the tecovirimat in water by using a combination of the cyclodextrin and meglumine, compared with the use of cyclodextrin alone or meglumine alone.