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1. (WO2018009923) METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/009923    International Application No.:    PCT/US2017/041277
Publication Date: 11.01.2018 International Filing Date: 08.07.2017
IPC:
C12N 15/10 (2006.01), C12N 15/867 (2006.01), C12N 5/0783 (2010.01), C12N 5/10 (2006.01), C07K 14/725 (2006.01), C07K 14/705 (2006.01), C07K 14/715 (2006.01), A61K 48/00 (2006.01)
Applicants: F1 ONCOLOGY, INC. [US/US]; 625 N. Flagler Dr. West Palm Beach, Florida 33401 (US)
Inventors: FROST, Gregory Ian; (US).
GUIBINGA, Ghiabe H.; (US).
ONUFFER, James Joseph; (US).
HAERIZADEH, Farzad; (US)
Agent: VACCHIANO, Emanuel J.; (US)
Priority Data:
62/360,041 08.07.2016 US
62/467,039 03.03.2017 US
15/462,855 19.03.2017 US
PCT/US2017/023112 19.03.2017 US
Title (EN) METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF
(FR) PROCÉDÉS ET COMPOSITIONS POUR LA TRANSDUCTION DE LYMPHOCYTES ET LA RÉGULATION DE L'ACTIVITÉ CORRESPONDANTE
Abstract: front page image
(EN)The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including ribos witches, MRB-CARs, recognition domains, and/or pH-modulating agents.
(FR)La présente invention concerne des procédés pour la modification génétique de lymphocytes et des procédés pour effectuer une thérapie cellulaire adoptive qui comprend la transduction de lymphocytes T et/ou de cellules tueuses naturelles. Les procédés comprennent une/des molécule(s) inhibitrice(s) d'ARN et/ou des polypeptides de signalisation manipulés qui peuvent comprendre un élément lymphoprolifératif et/ou un récepteur chimérique d'antigène (CAR), par exemple un CAR biologique limité à un microenvironnement (MRB-CAR). L'invention concerne également des éléments supplémentaires de ces polypeptides de signalisation manipulés, tels que ceux qui pilotent la prolifération et des éléments régulateurs correspondants, ainsi que des particules rétrovirales recombinantes incapables de réplication et des lignées cellulaires d'encapsidation et leurs procédés pour leur fabrication. L'invention concerne également de nombreux éléments et procédés de régulation de lymphocytes T et/ou de cellules NK transduit(e)s et/ou génétiquement modifié(e)s, tels que, par exemple, ceux comprenant des riborégulateurs, des MRB-CAR, des domaines de reconnaissance et/ou des agents de modulation du pH.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)