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1. (WO2018009916) ANTIBODY ADJUVANT CONJUGATES

Pub. No.:    WO/2018/009916    International Application No.:    PCT/US2017/041268
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Sat Jul 08 01:59:59 CEST 2017
IPC: A61K 45/00
C07K 16/30
C07K 16/28
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
BOLT BIOTHERAPEUTICS, INC.
Inventors: ALONSO, Michael Nathaniel
ENGLEMAN, Edgar George
ACKERMAN, Shelley Erin
KENKEL, Justin
LEE, Arthur
JACKSON, David Y.
Title: ANTIBODY ADJUVANT CONJUGATES
Abstract:
The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.