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1. (WO2018009905) IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS

Pub. No.:    WO/2018/009905    International Application No.:    PCT/US2017/041257
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Sat Jul 08 01:59:59 CEST 2017
IPC: A61B 5/00
A61N 1/36
A61N 1/378
A61N 1/372
A61N 1/05
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: MAHARBIZ, Michel, M.
CARMENA, Jose, M.
ANWAR, Mekhail
OZILGEN, Burak, A.
SEO, Dongjin
FAVA, Federica
Title: IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS
Abstract:
Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.