A reminder system and methods may be configured for medicine regimen compliance and monitoring. Embodiments may include a control device, a medicine container, a medicine identifier, a medicine container input device, a monitoring device and a portable electrical device. The control device, the medicine container input device and the monitoring device may include microprocessors, memories, input devices and output devices. The control device may provide operations including input and compare, by the microprocessor, a prescription and medicine information. The monitoring device may provide operations including compare, by the microprocessor, the medicine identifier of the medicine container and the medicine information. The monitoring device may also provide operations including determining, by the microprocessor, the amount of medication removed from the medicine container. The operations may further include generate, by the output device, an alert in response to the distance exceeding a threshold.