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1. (WO2018009625) SPIROLACTAMS AS INHIBITORS OF ROCK
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/009625 International Application No.: PCT/US2017/040850
Publication Date: 11.01.2018 International Filing Date: 06.07.2017
IPC:
C07D 401/14 (2006.01) ,C07D 403/10 (2006.01) ,C07D 471/10 (2006.01) ,C07D 487/10 (2006.01) ,C07D 491/10 (2006.01) ,A61K 31/407 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/12 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY[US/US]; Route 206 and Province Line Road Princeton, NJ 08543, US
Inventors: GLUNZ, Peter, W.; US
DELUCCA, Indawati; US
DILGER, Andrew K.; US
Agent: LIU, Hong; US
BELLOMY, Gregory, R.; US
CHAO, Yuan; US
CLAUSS, Isabelle, M.; US
DELAUNEY, Ashton, J.; US
EPPERSON, James; US
FARQUHARSON-TORRES, Serena; US
GOLIAN, Paul, D.; US
GREENBLATT, Gary, D.; US
GUO, Z., Angela; US
HADAD, Henry; US
HAI, Bing; US
JACOBSEN, Barry, H.; US
KORSEN, Elliott; US
LU, Yong; US
MINGO, Pamela, A.; US
PARLET, Nickki, L.; US
SUN, Jing, G.; US
VANATTEN, Mary, K.; US
VOM WEGE, Julia; US
WALSH, Brian, J.; US
Priority Data:
62/359,35407.07.2016US
Title (EN) SPIROLACTAMS AS INHIBITORS OF ROCK
(FR) SPIROLACTAMES UTILISÉS COMME INHIBITEURS DE RHO-KINASES (ROCK)
Abstract: front page image
(EN) The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
(FR) La présente invention concerne des composés de formule (I) : ou des stéréoisomères, des tautomères ou des sels pharmaceutiquement acceptables de ceux-ci, toutes les variables de la formule étant telles que définies dans la description. Ces composés sont des inhibiteurs sélectifs de ROCK. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, ainsi que des méthodes de traitement de troubles cardiovasculaires, des muscles lisses, oncologiques, neuropathologiques, auto-immuns, fibrotiques et/ou inflammatoires à l'aide desdites compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)