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1. (WO2018009609) SOLID FORMS OF AN SGC STIMULATOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/009609    International Application No.:    PCT/US2017/040827
Publication Date: 11.01.2018 International Filing Date: 06.07.2017
IPC:
C07D 413/14 (2006.01), A61K 31/4439 (2006.01), A61P 21/00 (2006.01)
Applicants: IRONWOOD PHARMACEUTICALS, INC. [US/US]; 301 Binney Street Cambridge, Massachusetts 02142 (US)
Inventors: SETHURAMAN, Vasu; (US).
HASHASH, Ahmad; (US).
XUE, Song; (US).
LIVINGSTON, Robert C.; (US).
NTI-ADDAE, Kwame Wiredu; (US)
Agent: DAVIS, Steven G.; (US)
Priority Data:
62/359,466 07.07.2016 US
Title (EN) SOLID FORMS OF AN SGC STIMULATOR
(FR) FORMES SOLIDES D'UN STIMULATEUR DE LA GCS
Abstract: front page image
(EN)The present disclosure relates to crystalline solid forms of a stimulator of soluble guanylate cyclase (sGC), Compound I. Also provided herein are methods for the preparation of these solid forms. The invention also relates to pharmaceutical formulations and dosage forms comprising these solid forms and their uses thereof, alone or in combination with one or more additional agents, for treating and/or preventing various diseases or disorders; these diseases or disorders are ones that may benefit from sGC stimulation or from an increase in the concentration of nitric oxide (NO) and/or cyclic guanosine monophosphate (cGMP).
(FR)La présente invention concerne des formes solides cristallines d'un stimulateur de la guanylate cyclase soluble (GCs), le composé I, ainsi que des procédés de préparation de ces formes solides. L'invention concerne également des formulations pharmaceutiques et des formes posologiques comprenant ces formes solides et leurs utilisations, seules ou en combinaison avec un ou plusieurs agents supplémentaires, pour le traitement et/ou la prévention de diverses maladies ou troubles ; ces maladies ou troubles sont ceux qui peuvent bénéficier d'une stimulation de la GCs ou d'une augmentation de la concentration en oxyde nitrique (NO) et/ou en guanosine monophosphate cyclique (GMPc)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)