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1. (WO2018009603) CHIMERIC WEST NILE/ZIKA VIRUSES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/009603    International Application No.:    PCT/US2017/040818
Publication Date: 11.01.2018 International Filing Date: 06.07.2017
IPC:
C07K 14/005 (2006.01), C12N 7/00 (2006.01), A61K 39/12 (2006.01)
Applicants: THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20852-7660 (US)
Inventors: KINNEY, Claire, Y.H.; (US)
Agent: CONNOLLY, Jodi L.; (US)
Priority Data:
62/359,807 08.07.2016 US
Title (EN) CHIMERIC WEST NILE/ZIKA VIRUSES AND METHODS OF USE
(FR) VIRUS CHIMÉRIQUES DU NIL OCCIDENTAL/ZIKA ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Chimeric flaviviruses that include non-coding regions, non- structural proteins, a capsid (C) protein and a portion of a premembrane (prM) signal sequence from West Nile virus (WNV), and a portion of a prM signal sequence, a prM protein and an E protein from Zika virus (VIKV) are described. Also described are compositions and methods for eliciting an immune response in a subject, such as an immune response directed against ZIKV. Diagnostic assays that utilize chimeric West Nile/Zika viruses are further described.
(FR)L'invention concerne des flavivirus chimériques qui comprennent des régions non codantes, des protéines non structurales, une protéine capside (C) et une partie d'une séquence de signal prémembranaire (prM) provenant du virus du Nil occidental (VNO), et une partie d'une séquence de signal prM, d'une protéine prM et d'une protéine E provenant du virus Zika (VZIK) sont décrites. L'invention concerne également des compositions et des procédés pour provoquer une réponse immune chez un sujet, telle qu'une réponse immune dirigée contre VZIK. L'invention concerne en outre des dosages diagnostiques qui utilisent les virus chimériques du Nil occidental/Zika.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)