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1. (WO2018009602) NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/009602    International Application No.:    PCT/US2017/040817
Publication Date: 11.01.2018 International Filing Date: 06.07.2017
IPC:
C07D 413/14 (2006.01), C07C 209/00 (2006.01), C07D 263/34 (2006.01), A61K 31/53 (2006.01), A61P 9/00 (2006.01)
Applicants: IRONWOOD PHARMACEUTICALS, INC. [US/US]; 301 Binney Street Cambridge, Massachusetts 02142 (US)
Inventors: XUE, Song; (US).
KARNATI, Vishnu Vardhan Reddy; (US).
LIVINGSTON, Robert C.; (US).
BARDEN, Timothy Claude; (US).
SCHAIRER, Wayne C.; (US)
Agent: DAVIS, Steven, G.; (US)
Priority Data:
62/359,430 07.07.2016 US
Title (EN) NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS
(FR) NOUVEAUX PROCÉDÉS DE PRÉPARATION DE STIMULATEURS DE LA GUANYLATE CYCLASE SOLUBLE
Abstract: front page image
(EN)The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound ( I), Compound (IA) and Compound (IB), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
(FR)L'invention concerne de nouveaux procédés de préparation de composés utiles en tant que stimulateurs de la guanylate cyclase soluble (sGC). Ces procédés peuvent être mis en oeuvre dans la préparation et la production à grande échelle de 3-(2-pyrimidinyl)pyrazoles stables de formule (I), notamment le composé (I), le composé (IA) et le composé (IB), avec une grande pureté et des rendements élevés. L'invention présente l'avantage supplémentaire de fournir des conditions de réaction simples pouvant être mises à l'échelle pour une fabrication à grande échelle. La présente invention concerne également de nouveaux intermédiaires utiles dans la préparation de ces composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)