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1. (WO2018009535) METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS

Pub. No.:    WO/2018/009535    International Application No.:    PCT/US2017/040708
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Thu Jul 06 01:59:59 CEST 2017
IPC: C12Q 1/68
G01N 33/574
Applicants: CASE WESTERN RESERVE UNIVERSITY
Inventors: MARKOWITZ, Sanford, D.
MOINOVA, Helen
CHAK, Amitabh
WILLIS, Joseph
LAFRAMBOISE, Thomas
Title: METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
Abstract:
The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.