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1. (WO2018009461) LISTERIA-BASED IMMUNOGENIC COMPOSITIONS COMPRISING WILMS TUMOR PROTEIN ANTIGENS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/009461 International Application No.: PCT/US2017/040459
Publication Date: 11.01.2018 International Filing Date: 30.06.2017
IPC:
C07K 14/47 (2006.01) ,C12N 15/74 (2006.01) ,A61K 39/00 (2006.01) ,A61K 48/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
ADVAXIS, INC. [US/US]; 305 College Road East Princeton, New Jersey 08540, US
Inventors:
PRINCIOTTA, Michael; US
PETIT, Robert; US
Agent:
SCHILLING, Stephen, H.; US
ALSTON & BIRD LLP; 101 South Tryon Street, Suite 4000 Charlotte, North Carolina 28280-4000, US
CHANG, Cindy; US
SKELTON, Bryan; US
KEITH, Jason A.; US
Priority Data:
62/358,53905.07.2016US
Title (EN) LISTERIA-BASED IMMUNOGENIC COMPOSITIONS COMPRISING WILMS TUMOR PROTEIN ANTIGENS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS IMMUNOGÈNES À BASE DE LISTERIA COMPRENANT DES ANTIGÈNES DE PROTÉINE TUMORALE DE WILMS ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
Abstract:
(EN) Provided are Listeria-based immunogenic compositions comprising Wilms tumor protein (WT1) antigens and methods for treating and vaccinating against cancer and inducing an immune response against the same in a subject. Also provided herein are recombinant fusion polypeptides or chimeric polypeptides comprising Wilms tumor protein antigens, nucleic acids encoding such chimeric polypeptides or fusion polypeptides, recombinant bacteria or Listeria strains comprising such chimeric polypeptides or fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such chimeric polypeptides or fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such chimeric polypeptides or fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-WT1 immune response in a subject, methods of inducing an anti-WT1-expressing-tumor or anti-WT1-expressing-cancer immune response in a subject, methods of treating a WT1-expressing or WT1-associated tumor or cancer in a subject, methods of preventing a WT1-expressing or WT1-associated tumor or cancer in a subject, and methods of protecting a subject against a WT1-expressing or WT1-associated tumor or cancer using such recombinant chimeric polypeptides or fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.
(FR) L'invention concerne des compositions immunogènes à base de Listeria comprenant des antigènes de protéine tumorale de Wilms (WT1) et des méthodes de traitement et de vaccination contre le cancer et d'induction d'une réponse immune contre celui-ci chez un sujet. L'invention concerne également des polypeptides de fusion recombinants ou des polypeptides chimériques comprenant des antigènes de protéine tumorale de Wilms, des acides nucléiques codant pour de tels polypeptides chimériques ou polypeptides de fusion, des souches recombinantes de bactéries ou de Listeria comprenant de tels polypeptides chimériques ou polypeptides de fusion ou de tels acides nucléiques et des bibliothèques de cellules comprenant de telles souches recombinantes de bactéries ou de Listeria. L'invention concerne également des procédés de génération de tels polypeptides chimériques ou polypeptides de fusion, de tels acides nucléiques et de telles souches recombinantes de bactéries ou de Listeria. L'invention concerne également des compositions immunogènes, des compositions pharmaceutiques et des vaccins comprenant de tels polypeptides chimériques ou polypeptides de fusion, de tels acides nucléiques ou de telles souches recombinantes de bactéries ou de Listeria. L'invention porte également sur des procédés d'induction d'une réponse immune anti-WT1 chez un sujet, sur des procédés d'induction d'une réponse immune anti-tumeur exprimant la WT1 ou anti-cancer exprimant la WT1 chez un sujet, des procédés de traitement d'une tumeur ou d'un cancer exprimant la WT1 ou associé(e) à la WT1 chez un sujet, des procédés de prévention d'une tumeur ou d'un cancer exprimant la WT1 ou associé(e) à la WT1 chez un sujet et des procédés de protection d'un sujet contre une tumeur ou un cancer exprimant la WT1 ou associé(e) à la WT1 à l'aide de tels polypeptides chimériques recombinants ou polypeptides de fusion, de tels acides nucléiques, de telles souches recombinantes de bactéries ou de Listeria, des compositions immunogènes, des compositions pharmaceutiques ou des vaccins.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)