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1. (WO2018008908) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE NEURONAL DISEASES, CONTAINING COMPOUND ISOLATED FROM WITHANIA COAGULANS AS ACTIVE INGREDIENT
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Pub. No.:    WO/2018/008908    International Application No.:    PCT/KR2017/006986
Publication Date: 11.01.2018 International Filing Date: 30.06.2017
IPC:
A61K 31/366 (2006.01), A61K 31/56 (2006.01), A61K 36/81 (2006.01), A23L 33/10 (2016.01)
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY [KR/KR]; 501, Jinju-daero Jinju-si Gyeongsangnam-do 52828 (KR)
Inventors: KIM, Myeong Ok; (KR)
Agent: PCR INTELLECTUAL PROPERTY LAW FIRM; 6F, Intel Building 70, Seolleung-ro 90-gil Gangnam-gu Seoul 06194 (KR)
Priority Data:
10-2016-0083944 04.07.2016 KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE NEURONAL DISEASES, CONTAINING COMPOUND ISOLATED FROM WITHANIA COAGULANS AS ACTIVE INGREDIENT
(FR) COMPOSITION PHARMACEUTIQUE POUR PRÉVENIR OU TRAITER DES MALADIES NEURONALES DÉGÉNÉRATIVES, CONTENANT UN COMPOSÉ ISOLÉ À PARTIR DE WITHANIA COAGULANS EN TANT QUE SUBSTANCE ACTIVE
(KO) 비타니아 코아귤란스에서 분리한 화합물을 유효성분으로 함유하는 퇴행성 신경질환의 예방 또는 치료용 약학적 조성물
Abstract: front page image
(EN)The present invention relates to a pharmaceutical composition for preventing or treating degenerative neuronal diseases, containing Coagulansin A as an active ingredient. Coagulansin-A has effects of promoting the expression of HSP70 and inhibiting the expression of BACE1 so as to inhibit the formation and aggregation of Aβ, thereby being usable as an active ingredient of a pharmaceutical composition for preventing or treating degenerative neuronal diseases.
(FR)La présente invention concerne une composition pharmaceutique pour prévenir ou traiter des maladies neuronales dégénératives, contenant de la coagulansine A en tant que substance active. La coagulansine A présente des effets de stimulation de l’expression de HSP70 et d’inhibition de l’expression de BACE1 de façon à inhiber la formation et l’agrégation de Aβ, de façon à être utilisable en tant que substance active d’une composition pharmaceutique pour prévenir ou traiter des maladies neuronales dégénératives.
(KO)본 발명은 코아귤란신 A를 유효성분으로 함유하는 퇴행성 신경질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 코아귤란신-A는 HSP70의 발현을 촉진하고, BACE1의 발현을 억제하여 Aβ의 생성 및 응집을 억제하는 효능이 있으므로 퇴행성 신경질환의 예방 또는 치료용 약학적 조성물의 유효성분으로 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)