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1. (WO2018008770) METHOD FOR CONTROLLING PERIPHERAL NERVE, METHOD FOR DEVELOPING FUNCTION TO ALTER FUNCTION OF NERVE CELL IN ORGANS EXCLUDING BRAIN AND SPINAL CORD AND OTHERS, NOVEL METHOD FOR PREVENTING OR TREATING DISEASE, AND MEDICINE FOR APPLICATION TO PERIPHERAL NERVES
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Pub. No.: WO/2018/008770 International Application No.: PCT/JP2017/025468
Publication Date: 11.01.2018 International Filing Date: 05.07.2017
IPC:
A61K 31/7088 (2006.01) ,A61K 35/76 (2015.01) ,A61K 48/00 (2006.01) ,A61P 25/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
76
Viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
02
for peripheral neuropathies
Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER[JP/JP]; 5-7-1, Fujishirodai, Suita-shi, Osaka 5658565, JP
Inventors: KAMIYA, Atsunori; JP
Agent: IWATANI, Ryo; KEIHAN Dojima Bldg. 6F, 1-31, Dojima 2-chome, Kita-ku, Osaka-shi, Osaka 5300003, JP
Priority Data:
2016-13464006.07.2016JP
2016-20469707.07.2016JP
Title (EN) METHOD FOR CONTROLLING PERIPHERAL NERVE, METHOD FOR DEVELOPING FUNCTION TO ALTER FUNCTION OF NERVE CELL IN ORGANS EXCLUDING BRAIN AND SPINAL CORD AND OTHERS, NOVEL METHOD FOR PREVENTING OR TREATING DISEASE, AND MEDICINE FOR APPLICATION TO PERIPHERAL NERVES
(FR) PROCÉDÉ DE CONTRÔLE DU NERF PÉRIPHÉRIQUE ET DE MODIFICATION DE LA FONCTION DE LA CELLULE NERVEUSE.
(JA) 末梢神経を操作する方法、脳および脊髄を除く臓器などにおいて神経細胞機能を変化させる機能を発生させる方法、および新規疾病の予防または治療方法、ならびに末梢神経投与用医薬
Abstract:
(EN) Provided is a method for preventing or treating a disease, said method being characterized in that a viral vector having, integrated thereinto, a gene encoding a protein having a function to kill, stimulate or depress peripheral nerves or a function to alter another nerve cell function is injected topically to an organ excluding brain and spinal cord, a tumor or an area that has undergone tumor resection to cause the infection of the nerves with the viral vector and consequently cause the expression of the protein having the above-mentioned function in the infected nerves, whereby the function of the nerves infected with the viral vector is controlled by the protein so that the function of the organ, excluding brain and spinal cord, to which the nerves are connected is altered. The method can be utilized for providing a therapeutic medicine and a treatment means in the medical industry. Particularly in cancer therapies, this method can be utilized widely both domestically and abroad in such a way that the viral vector is injected topically to a remaining cancer tissue postoperatively to suppress the recurrence or metastasis of the cancer.
(FR) L'invention porte sur un procédé de prévention, ou de traitement, d'une maladie utilisant un vecteur viral avec un gène codant pour une protéine ayant pour fonction de détruire, stimuler ou d'atténuer les nerfs périphériques. Le gène peut également modifier la fonction de la cellule nerveuse injectée localement sur un organe, à l'exclusion du cerveau et de la moelle épinière, une tumeur ou une zone ayant subi une résection tumorale. Ceci provoque l'infection des nerfs avec le vecteur viral et par conséquent l'expression de la protéine ayant la fonction mentionnée ci-dessus dans les nerfs infectés. La fonction des nerfs infectés, par le vecteur viral, est régulée par la protéine de sorte que la fonction de l'organe inervé est modifiée. Ce procédé peut être utilisé dans l'industrie médicale comme outils de traitement, en particulier, dans les thérapies anticancéreuses. Le vecteur viral est injecté localement dans un tissu cancéreux post-opératoire restant, afin de supprimer la récurrence ou la métastase du cancer.
(JA) 末梢神経を、死滅させる、刺激する、抑制する、またはその他の神経細胞機能を変化させる機能を有するタンパク質をコードする遺伝子を組み込んだウイルスベクターを、脳および脊髄を除く臓器、腫瘍または腫瘍を切除した部位に局所注入し、前記ウイルスベクターを前期神経に感染させ、感染した神経内で前記機能を有するタンパク質を発現させ、該タンパク質により前記ウイルスベクターに感染した神経の機能を操作し、該神経が連絡している該脳および脊髄を除く臓器の機能を変化させることを特徴とする、疾病の予防または治療方法を提供する。医療産業に治療薬および治療手段として活用できる。特に、がん医療においては、術後にがんの残組織にウイルスベクターを局所注入して再発や転移を抑制するような形で、国内外で、広く使用され得る。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)