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1. (WO2018008153) METHOD FOR DETERMINING POSSIBILITY OF ONSET OF COLON CANCER

Pub. No.:    WO/2018/008153    International Application No.:    PCT/JP2016/070330
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Sat Jul 09 01:59:59 CEST 2016
IPC: C12Q 1/68
C12N 15/09
G01N 33/48
G01N 33/50
Applicants: HANUMAT CO., LTD.
有限会社ハヌマット
EA PHARMA CO., LTD.
EAファーマ株式会社
Inventors: KUSUNOKI Masato
楠 正人
TOIYAMA Yuji
問山 裕二
TANAKA Koji
田中 光司
ARAKI Toshimitsu
荒木 俊光
MITSUI Akira
三井 彰
TAKEHANA Kenji
竹鼻 健司
UMEZAWA Tsutomu
梅澤 努
Title: METHOD FOR DETERMINING POSSIBILITY OF ONSET OF COLON CANCER
Abstract:
The present invention is a method for determining the possibility of the onset of colon cancer in human ulcerative colitis patients, wherein the method for determining the possibility of onset of colon cancer includes a measurement step for measuring the methylation rate of one or more CpG sites selected from the group consisting of CpG sites in base sequences represented by SEQ ID NOS: 1-80 in DNA recovered from a biological sample collected from a human ulcerative colitis patient, and a determination step for determining the possibility of onset of colon cancer in the human ulcerative colitis patient on the basis of the methylation rate measured in the measurement step and a preset reference value or preset multivariate discriminant.