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1. (WO2018008017) CIRCULATING MICRORNAS AS BIOMARKERS FOR THERAPY IN NEUROMYELITIS OPTICA (NMO) AND MULTIPLE SCLEROSIS (MS)
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/008017 International Application No.: PCT/IL2017/050741
Publication Date: 11.01.2018 International Filing Date: 03.07.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/564 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
564
for pre-existing immune complex or autoimmune disease
Applicants: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.[IL/IL]; P.O. Box 12000 9112001 Jerusalem, IL
Inventors: LAVON BEN MOSHE, Iris; IL
VAKNIN-DEMBINSKY, Adi; IL
Agent: WEBB, Cynthia; Webb & CO. P.O. BOX 2189 7612101 REHOVOT, IL
WEBB, Cynthia; IL
BARZAM, Maty; IL
BOGIN, Liora; IL
BURSTEIN, Tal; IL
FINAROV, Igal; IL
GANOR, Sharon; IL
HORNIK, Vered; IL
NOAH, Eran; IL
POTASH, Shay; IL
SCHICKLER, Hedva; IL
SCHVARTZ, Iris; IL
SILVERMAN, Eran; IL
TRAVITSKY, Nina; IL
WEBB, Yael; IL
ZIPOR, Gadi; IL
Priority Data:
62/358,01503.07.2016US
Title (EN) CIRCULATING MICRORNAS AS BIOMARKERS FOR THERAPY IN NEUROMYELITIS OPTICA (NMO) AND MULTIPLE SCLEROSIS (MS)
(FR) MICRO-ARN CIRCULANTS EN TANT QUE BIOMARQUEURS POUR UNE THÉRAPIE DANS LA NEUROMYÉLITE OPTIQUE (NMO) ET DE LA SCLÉROSE EN PLAQUES (SEP)
Abstract:
(EN) The invention relates to circulating micro RNAs as biomarkers in Neuromyelitis Optica (NMO) and/or multiple sclerosis (MS). The invention further relates to circulating mi RNA profile for the prediction of responsiveness to treatment, such as, rituximab, of subjects afflicted with NMO and/or MS.
(FR) L'invention concerne des micro-ARN circulants en tant que biomarqueurs dans la neuromyélite optique (NMO) et/ou la sclérose en plaques (SEP). L'invention concerne en outre un profil de miARN circulants pour la prédiction de la sensibilité à un traitement, tel que le rituximab, de sujets souffrant de NMO et/ou de SEP.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)