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1. (WO2018007950) HUMANIZED ANTIBODIES TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/007950 International Application No.: PCT/IB2017/054036
Publication Date: 11.01.2018 International Filing Date: 04.07.2017
IPC:
C07K 16/46 (2006.01) ,A61K 39/395 (2006.01) ,A61K 47/68 (2017.01) ,C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
[IPC code unknown for A61K 47/68]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA[CA/CA]; 1200 Montreal Road Ottawa, Ontario K1A 0R6, CA
Inventors: STANIMIROVIC, Danica; CA
KEMMERICH, Kristin; CA
DUROCHER, Yves; CA
SULEA, Traian; CA
Agent: THOMAS, Roula; CA
SMITH, Jessica; CA
DAVIS, Jason E. J.; CA
LEMAY, Catherine; CA
PATENAUDE, Sonia; CA
PICHE, Christine; CA
Priority Data:
62/358,77706.07.2016US
Title (EN) HUMANIZED ANTIBODIES TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOF
(FR) ANTICORPS HUMANISÉS FRANCHISSANT LA BARRIÈRE HÉMATOENCÉPHALIQUE ET LEURS UTILISATIONS
Abstract:
(EN) The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.
(FR) La présente invention concerne des anticorps et des fragments correspondants obtenus par humanisation d'un anticorps existant, et leurs procédés de fabrication. Les anticorps humanisés selon l'invention présentent une plus forte liaison à l'antigène des cellules endothéliales cérébrales, une meilleure aptitude à franchir la barrière hématoencéphalique, et une plus grande stabilité thermique par rapport à l'anticorps parent non humanisé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)