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1. (WO2018007950) HUMANIZED ANTIBODIES TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/007950    International Application No.:    PCT/IB2017/054036
Publication Date: 11.01.2018 International Filing Date: 04.07.2017
IPC:
C07K 16/46 (2006.01), A61K 39/395 (2006.01), A61K 47/68 (2017.01), C07K 16/00 (2006.01)
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA [CA/CA]; 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA)
Inventors: STANIMIROVIC, Danica; (CA).
KEMMERICH, Kristin; (CA).
DUROCHER, Yves; (CA).
SULEA, Traian; (CA)
Agent: THOMAS, Roula; (CA).
SMITH, Jessica; (CA).
DAVIS, Jason E. J.; (CA).
LEMAY, Catherine; (CA).
PATENAUDE, Sonia; (CA).
PICHE, Christine; (CA)
Priority Data:
62/358,777 06.07.2016 US
Title (EN) HUMANIZED ANTIBODIES TRANSMIGRATING THE BLOOD-BRAIN BARRIER AND USES THEREOF
(FR) ANTICORPS HUMANISÉS FRANCHISSANT LA BARRIÈRE HÉMATOENCÉPHALIQUE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.
(FR)La présente invention concerne des anticorps et des fragments correspondants obtenus par humanisation d'un anticorps existant, et leurs procédés de fabrication. Les anticorps humanisés selon l'invention présentent une plus forte liaison à l'antigène des cellules endothéliales cérébrales, une meilleure aptitude à franchir la barrière hématoencéphalique, et une plus grande stabilité thermique par rapport à l'anticorps parent non humanisé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)