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1. (WO2018007923) ANTI-TRANSTHYRETIN ANTIBODIES

Pub. No.:    WO/2018/007923    International Application No.:    PCT/IB2017/053987
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Sat Jul 01 01:59:59 CEST 2017
IPC: C07K 16/18
A61K 39/00
Applicants: PROTHENA BIOSCIENCES LIMITED
UNIVERSITY HEALTH NETWORK
Inventors: NIJJAR, Tarlochan S.
CHAKRABARTTY, Avijit
HIGAKI, Jeffrey N
Title: ANTI-TRANSTHYRETIN ANTIBODIES
Abstract:
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.