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1. (WO2018007803) METHODS FOR DIAGNOSING MOTOR NEURON DISEASES

Pub. No.:    WO/2018/007803    International Application No.:    PCT/GB2017/051971
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Wed Jul 05 01:59:59 CEST 2017
IPC: G01N 33/68
G01N 33/92
Applicants: GRIFFITHS, William
CRICK, Peter
WANG, Yuqin
KUHLE, Jens
SAILER, Andreas
ZHANG, Juan
TURNER, Martin
Inventors: GRIFFITHS, William
CRICK, Peter
WANG, Yuqin
KUHLE, Jens
SAILER, Andreas
ZHANG, Juan
TURNER, Martin
Title: METHODS FOR DIAGNOSING MOTOR NEURON DISEASES
Abstract:
The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.