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1. (WO2018007555) METHOD FOR DIAGNOSING CANCER

Pub. No.:    WO/2018/007555    International Application No.:    PCT/EP2017/067013
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Fri Jul 07 01:59:59 CEST 2017
IPC: G01N 33/574
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
INSTITUT JEAN PAOLI & IRENE CALMETTES
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
UNIVERSITÉ D'AIX MARSEILLE
ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
Inventors: CAMOIN, Luc
PELTIER, Julien
ROPERCH, Jean-Pierre
Title: METHOD FOR DIAGNOSING CANCER
Abstract:
The present invention relates the diagnosis of cancer field. After a high resolution mass spectrometry-based proteomic strategy in different clinical stages of CRC, the inventors identified peptide fragments from the coagulation factor XIII A chain (AP-F13A1). These fragments seem to be useful to distinguished healthy patients from patients with adenomatous polyps and CRC. They develop and describe the outstanding potential of LC-MS/MS and SRM assays for quantifying and validating the use of AP-F13A1 as a biomarker of colorectal cancer. More, the inventors develop another proteomic strategy able to find others biomarkers that are altered in CRC. Their results suggest that highlighted proteins SERPINAl, SERPINA3 and SERPINC1 and factor XIII Al peptides, may help for diagnosing CRC and may help in pre- selecting patients with mild symptoms or without prior history of CRC for colonoscopy. Thus, the present invention relates to a method for diagnosing cancer in a subject comprising a step consisting of detecting the level of at least one AP-F13A1 peptide in a sample obtained from said subject.