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1. (WO2018007428) MEANS AND METHODS FOR THE GENERATION OF OLIGODENDROCYTES

Pub. No.:    WO/2018/007428    International Application No.:    PCT/EP2017/066729
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Thu Jul 06 01:59:59 CEST 2017
IPC: C12N 5/079
Applicants: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER
Inventors: EHRLICH, Marc
KUHLMANN, Tanja
Title: MEANS AND METHODS FOR THE GENERATION OF OLIGODENDROCYTES
Abstract:
The present invention relates to methods of generating oligodendroglial lineage cells from human cells selected from the group consisting of neural progenitor cells (NPCs), pluripotent stem cells (PSCs), induced pluripotent stem cells (iPSCs) and fibroblasts. The invention furthers relates to methods of screening for a compound promoting oligodendroglial differentiation and/or maturation, specifically to high throughput methods. In addition, the invention relates to cells obtainable by these methods and use of these cells in therapy.