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1. (WO2018007327) A UNIVERSAL ASSAY FOR DETERMINING THE QUANTITY OF THERAPEUTIC MONOCLONAL ANTIBODIES AND THEIR CORRESPONDING ANTI-DRUG-ANTIBODIES IN SAMPLES
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Pub. No.:    WO/2018/007327    International Application No.:    PCT/EP2017/066515
Publication Date: 11.01.2018 International Filing Date: 03.07.2017
IPC:
G01N 33/53 (2006.01), G01N 33/542 (2006.01), G01N 33/68 (2006.01)
Applicants: ATONOMICS A/S [DK/DK]; Vestre Teglgade 10 2450 Copenhagen SV (DK)
Inventors: WARTHOE, Peter; (DK).
HENRIK RINDEL, Gudbergsen; (DK)
Agent: COPA COPENHAGEN PATENTS; Rosenørns Allé 1, 2nd floor 1970 Frederiksberg C (DK)
Priority Data:
PA 2016 70515 08.07.2016 DK
Title (EN) A UNIVERSAL ASSAY FOR DETERMINING THE QUANTITY OF THERAPEUTIC MONOCLONAL ANTIBODIES AND THEIR CORRESPONDING ANTI-DRUG-ANTIBODIES IN SAMPLES
(FR) DOSAGE UNIVERSEL POUR DÉTERMINER LA QUANTITÉ D'ANTICORPS MONOCLONAUX THÉRAPEUTIQUES ET LEURS ANTICORPS ANTI-MÉDICAMENT CORRESPONDANTS DANS DES ÉCHANTILLONS
Abstract: front page image
(EN)The present invention relates to a kit of parts and methods for determining the presence and quantity of one or more therapeutic monoclonal antibody drugs and/or therapeutic monoclonal antibody inhibitor drug antibodies in a biological sample, the method comprising the steps of providing a reaction liquid comprising the sample, a first conjugate comprising the target of the therapeutic monoclonal antibody and a first conjugated moiety and a second conjugate comprising the target of the therapeutic monoclonal antibody and a second conjugated moiety, followed by detecting the change in spectrophotometric signal when the complex between the therapeutic monoclonal antibody drug, the first conjugate and a the second conjugate forms.
(FR)La présente invention concerne un kit de composants et des procédés pour déterminer la présence et la quantité d'un ou plusieurs médicaments anticorps monoclonaux thérapeutiques et/ou anticorps anti-médicament inhibiteurs d'anticorps monoclonal thérapeutique dans un échantillon biologique, le procédé comprenant les étapes de fourniture d'un liquide de réaction comprenant l'échantillon, un premier conjugué comprenant la cible de l'anticorps monoclonal thérapeutique et un premier fragment conjugué et un deuxième conjugué comprenant la cible de l'anticorps monoclonal thérapeutique et un deuxième fragment conjugué, suivie de la détection du changement de signal spectrophotométrique lorsque le complexe entre le médicament anticorps monoclonal thérapeutique, le premier conjugué et le deuxième conjugué se forme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)