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1. (WO2018007035) PROCESS FOR THE PURIFICATION OF METHYLCOBALAMIN

Pub. No.:    WO/2018/007035    International Application No.:    PCT/EP2017/057506
Publication Date: Fri Jan 12 00:59:59 CET 2018 International Filing Date: Fri Mar 31 01:59:59 CEST 2017
IPC: C07H 1/06
C07H 23/00
Applicants: INTERQUIM, S.A.
Inventors: SALLARES ROSELL, Juan
MARQUILLAS OLONDRIZ, Francisco
Title: PROCESS FOR THE PURIFICATION OF METHYLCOBALAMIN
Abstract:
The present invention relates to a process for the purification of methylcobalamin, namely from iron cyanide impurities, comprising contacting a solution comprising methylcobalamin and iron cyanide anions with a strongly basic anion exchange resin. This purification process can advantageously be used for removing iron cyanide impurities from methylcobalamin obtained by reductive methylation of cyanocobalamin and wherein iron (II) salts are used as cyanide scavengers, thus providing methylcobalamin with a reduced iron content. Methylcobalamin (R is methyl).