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1. (WO2018006880) CO-EXPRESSION OF RECOMBINANT IMMUNE-CHECKPOINT RECEPTOR AND IMMUNE-CHECKPOINT INHIBITOR AND APPLICATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/006880 International Application No.: PCT/CN2017/092376
Publication Date: 11.01.2018 International Filing Date: 10.07.2017
IPC:
C07K 19/00 (2006.01) ,C12N 15/62 (2006.01) ,C12N 7/01 (2006.01) ,C12N 5/10 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
Applicants: LIFESEQ LIMITED CORPORATION[CN/CN]; Room 301, No. 22, International Hua Cheng, 1515 Zhangyang Road, Pudong New Area Shanghai 200120, CN
Inventors: CHEN, Siyi; CN
Agent: TSINGYIHUA INTELLECTUAL PROPERTY LLC; Room 301 Trade Building, Zhaolanyuan, Tsinghua University, Qinghuayuan, Haidian District Beijing 100084, CN
Priority Data:
201610537696.008.07.2016CN
Title (EN) CO-EXPRESSION OF RECOMBINANT IMMUNE-CHECKPOINT RECEPTOR AND IMMUNE-CHECKPOINT INHIBITOR AND APPLICATION
(FR) CO-EXPRESSION D'UN RÉCEPTEUR DE POINT DE CONTRÔLE IMMUNITAIRE RECOMBINANT ET D'UN INHIBITEUR DU POINT DE CONTRÔLE IMMUNITAIRE ET APPLICATION
(ZH) 重组免疫检查点受体及免疫检查点抑制分子的共表达及应用
Abstract:
(EN) A transgenic lymphocyte, a construct, and a therapeutic composition for treating cancer. The transgenic lymphocyte has a silenced cellular immune-checkpoint and expresses a recombinant receptor. The recombinant receptor comprises: a cellular immune-checkpoint molecular segment; an immune stimulator molecular segment; and a T-cell receptor zeta chain.
(FR) La présente invention concerne un lymphocyte transgénique, une construction et une composition thérapeutique pour le traitement du cancer. Le lymphocyte transgénique a un point de contrôle immunitaire cellulaire inactivé et exprime un récepteur recombinant. Le récepteur recombinant comprend : un segment moléculaire de point de contrôle immuno-cellulaire; un segment moléculaire du stimulateur immunitaire; et une chaîne zêta du récepteur de lymphocytes T.
(ZH) 一种转基因淋巴细胞、一种构建体和一种治疗癌症的治疗组合物,该转基因淋巴细胞的细胞免疫检查点被沉默以及表达重组受体,该重组受体包括:细胞免疫检查点分子片段;免疫刺激分子片段;以及T细胞受体zeta链。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)