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1. (WO2018006750) NOVEL NATURAL PROTEIN AND APPLICATION THEREOF
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Pub. No.: WO/2018/006750 International Application No.: PCT/CN2017/090785
Publication Date: 11.01.2018 International Filing Date: 29.06.2017
Chapter 2 Demand Filed: 27.11.2017
IPC:
C07K 14/47 (2006.01) ,C07K 19/00 (2006.01) ,C12N 15/12 (2006.01) ,C12N 5/10 (2006.01) ,C12N 15/85 (2006.01) ,C12N 15/861 (2006.01) ,C12N 15/867 (2006.01) ,A61K 38/17 (2006.01) ,A61K 45/00 (2006.01) ,A61K 48/00 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants: SHANGHAI CLEAR FLUID BIOMEDICAL SCIENCE CO., LTD.[CN/CN]; Room 420, Building 26, Lane 3399 Kangxin Road, Pudong New Area Shanghai 200120, CN
Inventors: ZHANG, Yinghao; CN
FU, Jingpeng; CN
WAN, Jia; CN
Agent: BEIJING UTC LIANFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); Floor 1-4, Building A9-A10, No.231-233, Science Avenue Economic & Technological Development District Guangzhou, Guangdong 510000, CN
Priority Data:
201610519038.904.07.2016CN
Title (EN) NOVEL NATURAL PROTEIN AND APPLICATION THEREOF
(FR) NOUVELLE PROTÉINE NATURELLE ET SON APPLICATION
(ZH) 一种新型天然蛋白及其应用
Abstract:
(EN) Provided is a secretory protein sDSS1 of a higher primate. The sDSS1 protein can bind, under non-enzymatic conditions, with an oxidized protein to form a polymer, or bind with an Aβ polypeptide to reduce the formation of an Aβ oligomer. The sDSS1 protein can shield against cytotoxicity induced by an oxidized protein, Aβ oligomer, amylin oligomer, or glycosylated protein. The protein can be used to prevent and treat a disease caused by accumulation of an oxidized protein, glycoprotein, Aβ protein, or amylin, or by the generation or accumulation of another pathogenic protein with a similar property.
(FR) L'invention concerne une protéine sécrétrice sDSS1 d'un primate supérieur. La protéine peut être détectée dans le sérum sanguin et dans le liquide céphalorachidien chez l'homme. La protéine sDSS1 peut se lier, dans des conditions non enzymatiques, à une protéine oxydée pour former un polymère, ou se lier à un polypeptide Aβ pour réduire la formation d'un oligomère Aβ. En culture, la protéine sDSS1 peut protéger contre la cytotoxicité induite par une protéine oxydée, un oligomère Aβ, un oligomère d'amyline ou une protéine glycosylée. La protéine sDSS1 peut prolonger de manière significative la survie d'un modèle de souris progeria. La protéine peut être utilisée pour prévenir et traiter une maladie provoquée par l'accumulation d'une protéine oxydée, d'une glycoprotéine, d'une protéine Aβ ou de l'amyline, ou par la génération ou l'accumulation d'une autre protéine pathogène ayant une propriété similaire.
(ZH) 本发明提供了一种高等灵长类动物的分泌型蛋白sDSS1。sDSS1蛋白在非酶促条件下可以与氧化蛋白结合形成聚合物或与Aβ多肽结合降低Aβ寡聚物形成,可以屏蔽氧化蛋白、Αβ寡聚物、Amylin寡聚物、糖基化蛋白引起的细胞毒性。该蛋白可用于预防和治疗氧化蛋白、糖化蛋白、Αβ蛋白累积、Amylin蛋白累积或其他相似特征致病蛋白过渡生成或积累引起的疾病。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)