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1. (WO2018006092) AMINO ACID COPOLYMER COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/006092    International Application No.:    PCT/US2017/040598
Publication Date: 04.01.2018 International Filing Date: 03.07.2017
IPC:
A61K 39/00 (2006.01), A61K 31/74 (2006.01), A61P 37/04 (2006.01), A61P 25/28 (2006.01)
Applicants: DECLION HOLDINGS LLC [US/US]; 3 Ashland Road Boxford, MA 01921 (US)
Inventors: ZANELLI, Eric; (US)
Agent: RONES, Melissa S.; (US).
CHIMALAKONDA, Gitanjali; (US).
RONES, Melissa, S.; (US)
Priority Data:
62/478,410 29.03.2017 US
62/357,800 01.07.2016 US
Title (EN) AMINO ACID COPOLYMER COMPOSITIONS AND USES THEREOF
(FR) COMPOSÉS D'AMINO ACIDES DE COPOLYMÈRES ET LEURS APPLICATIONS.
Abstract: front page image
(EN)The instant disclosure describes compositions comprising mixtures of polypeptides comprising one or more antigenic regions and one or more random copolymer regions. In certain embodiments, the amino acid copolymer compositions of the disclosure are capable of acting as antigen specific therapeutics and are useful as vaccines, such compositions synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids at each position along the length of the polypeptides. The resulting compositions are mixtures of related polypeptides for numerous therapeutic, research and diagnostic uses.
(FR)L'invention décrit un mélange de polypeptides comprenant une, ou plusieurs régions antigéniques, et une ou plusieurs régions de copolymères aléatoires. Les composés de copolymères d'acides aminés sont capables d'agir en tant qu'agents thérapeutiques spécifiques d'antigènes, et peuvent être utilisé comme vaccins. De telles composés sont synthétisées selon un ensemble de règles concernant l'identité et la fréquence d'occurrence d'acides aminés à chaque position le long des polypeptides. Les composés ainsi obtenues sont utilisées pour de nombreuses applications thérapeutiques, de recherche et de diagnostique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)