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1. (WO2018006052) COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA
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Pub. No.: WO/2018/006052 International Application No.: PCT/US2017/040446
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
C12N 15/11 (2006.01) ,A61K 8/14 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
02
characterised by special physical form
14
Liposomes
Applicants:
ARBUTUS BIOPHARMA CORPORATION [CA/CA]; 100-8900 Glenlyon Parkway Burnaby, British Columbia V5J 5J8, CA
Inventors:
ABRAMS, Michael J.; CA
HEYES, James; CA
JUDGE, Adam; CA
LAM, Kieu Mong; CA
PALMER, Lorne Ralph; CA
REID, Stephen P.; CA
YAWORSKI, Edward D.; CA
Agent:
MALEN, Peter L.; US
HARRIS, Robert J.; US
VIKSNINS, Ann S.; US
KRUEGER, Katherine A.D.; US
MICKELSON, John W.; US
KLIMA SILBERG, Catherine I.; US
LI, Yang; US
PADYS, Danny J.; US
Priority Data:
62/357,18930.06.2016US
62/375,29215.08.2016US
Title (EN) COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA
(FR) COMPOSITIONS ET PROCÉDÉS POUR L'ADMINISTRATION D'ARN MESSAGER
Abstract:
(EN) The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease.
(FR) La présente invention concerne des compositions comprenant des molécules d'acide nucléique, telles que des molécules d'ARNm, encapsulées dans des particules lipidiques. Les compositions sont utiles, par exemple, pour introduire les molécules d'ARNm dans un sujet humain où elles sont traduites pour produire un polypeptide qui agit de manière à améliorer un ou plusieurs symptômes d'une maladie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)