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1. (WO2018006039) METHODS OF MODULATING MELANOSOME PH AND MELANIN LEVEL IN CELLS
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Pub. No.: WO/2018/006039 International Application No.: PCT/US2017/040428
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
A61K 31/4015 (2006.01) ,A61K 31/4025 (2006.01) ,A61K 31/4152 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4015
having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4152
having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
Applicants: CORNELL UNIVERSITY[US/US]; Center for Technology Licensing at Cornell University ("CTL") 395 Pine Tree Road, Suite 310 Ithaca, New York 14850, US
Inventors: ZIPPIN, Jonathan; US
Agent: GASE, John L.; US
LEYDIG, VOIT & MAYER, LTD.; Two Prudential Plaza, Suite 4900 180 N. Stetson Ave. Chicago, Illinois 60601-6731, US
Priority Data:
62/357,60601.07.2016US
62/480,18931.03.2017US
Title (EN) METHODS OF MODULATING MELANOSOME PH AND MELANIN LEVEL IN CELLS
(FR) PROCÉDÉS DE MODULATION DU PH DES MÉLANOSOMES ET DE LA TENEUR EN MÉLANINE DANS DES CELLULES
Abstract:
(EN) The invention is directed to compositions and methods for increasing the pH of a melanosome in a melanocyte, darkening skin or hair pigmentation, or treating a disease associated with decreased melanin comprising administering a soluble adenylyl cyclase (sAC) inhibitor and/or an exchange protein activated by cyclic AMP (EPAC) inhibitor to the melanocyte. The invention also provides compositions and methods for decreasing the pH of a melanosome in a melanocyte, lightening skin or hair pigmentation, or treating a disease associated with increased melanin comprising administering a sAC activator and/or an EPAC activator to the melanocyte.
(FR) L'invention concerne des compositions et des procédés permettant d'augmenter le pH d'un mélanosome dans un mélanocyte, de foncer la peau ou la pigmentation pileuse, ou de traiter une maladie associée à une diminution de la mélanine comprenant l'administration d'un inhibiteur de l'adénylyle cyclase soluble (sAC) et/ou d'une protéine d'échange activée par un inhibiteur de l'AMP cyclique (EPAC) au mélanocyte. L'invention concerne également des compositions et des procédés permettant de diminuer le pH d'un mélanosome dans un mélanocyte, d'éclaircir la peau ou la pigmentation pileuse, ou de traiter une maladie associée à une augmentation de la mélanine, comprenant l'administration d'un activateur de sAC et/ou d'un activateur d'EPAC au mélanocyte.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)