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1. (WO2018006031) PRINS REACTION AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/006031    International Application No.:    PCT/US2017/040401
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
C07D 493/22 (2006.01), C07D 321/00 (2006.01)
Applicants: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-chome Tokyo, 112-8088 (JP).
CHASE, Charles, E. [US/US]; (US) (US only).
CHOI, Hyeong-Wook [KR/US]; (US) (US only).
ENDO, Atsushi [JP/US]; (US) (US only).
FANG, Francis, G. [US/US]; (US) (US only).
KIM, Dae-Shik [KR/US]; (US) (US only)
Inventors: CHASE, Charles, E.; (US).
CHOI, Hyeong-Wook; (US).
ENDO, Atsushi; (US).
FANG, Francis, G.; (US).
KIM, Dae-Shik; (US)
Agent: MCDONALD, J., Cooper; (US)
Priority Data:
62/357,031 30.06.2016 US
Title (EN) PRINS REACTION AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF
(FR) RÉACTION DE PRINS ET D'INTERMÉDIAIRES UTILES DANS LA SYNTHÈSE DE MACROLIDES D'HALICHONDRINE ET DE SES ANALOGUES
Abstract: front page image
(EN)The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
(FR)L'invention concerne des procédés pour la synthèse de macrolides halichondrine ou de ses analogues par le biais d'une stratégie de réaction de cyclisation. La stratégie de la présente invention consiste à soumettre un intermédiaire à des conditions de réaction de Prins pour obtenir un macrolide. L'invention porte également sur des composés utiles comme intermédiaires dans la synthèse de macrolides halichondrine ou ses analogues et sur des procédés de préparation de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)