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1. (WO2018005974) OLIGONUCLEOTIDES COMPRISING MODIFIED NUCLEOSIDES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/005974    International Application No.:    PCT/US2017/040299
Publication Date: 04.01.2018 International Filing Date: 30.06.2017
IPC:
C12N 15/115 (2010.01), C12N 15/11 (2006.01), A61K 31/7115 (2006.01)
Applicants: SOMALOGIC, INC. [US/US]; 2945 Wilderness Place Boulder, Colorado 80301 (US)
Inventors: CARTER, Jeff; (US).
GAWANDE, Bharat; (US).
JANJIC, Nebojsa; (US).
SCHNEIDER, Daniel; (US)
Agent: SCARR, Rebecca; (US).
BAUR, Amelia; (US).
MCNEILL, Rebecca; (US).
HENNINGER, Mary; (US).
DOHERTY, Elizabeth; (US).
BREIER, Adam; (US).
HERZFELD, Deborah; (US).
PRYBYLOWSKI, Kate; (US).
LEE, Victoria; (US)
Priority Data:
62/357,623 01.07.2016 US
62/437,592 21.12.2016 US
Title (EN) OLIGONUCLEOTIDES COMPRISING MODIFIED NUCLEOSIDES
(FR) OLIGONUCLÉOTIDES COMPRENANT DES NUCLÉOSIDES MODIFIÉS
Abstract: front page image
(EN)Polynucleotides, such as aptamers, comprising at least first one 5-position modified pyrimidine and at least one second 5-position modified pyrimidine are provided, wherein the first and second 5-position modified pyrimidines are different. Methods of selecting and using such polynucleotides, such as aptamers, are also provided.
(FR)L'invention concerne des polynucléotides, tels que des aptamères, comprenant au moins une première pyrimidine modifiée en position 5 et au moins une seconde pyrimidine modifiée en position 5, les première et seconde pyrimidine modifiée en position 5 étant différentes. L'invention concerne également des procédés de sélection et d'utilisation de ces polynucléotides, tels que des aptamères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)