WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018005801) NOVEL NON-SYSTEMIC TGR5 AGONISTS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/005801    International Application No.:    PCT/US2017/040010
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C07F 7/18 (2006.01), C07D 233/74 (2006.01)
Applicants: VENENUM BIODESIGN LLC [US/US]; 8 Black Forest Road Lawrence Township, New Jersey 08648 (US)
Inventors: HUANG, Chia-Yu; (US).
SHI, Dongchuan; (US).
KULTGEN, Steven G.; (US).
MCGUINNESS, Brian F; (US).
STEIN, Philip D.; .
LETOURNEAU, Jeffrey J.; (US).
COLE, Andrew G.; (US).
BEASLEY, James R.; (US)
Agent: DOWNING, Jessica A; (US)
Priority Data:
62/357,433 01.07.2016 US
Title (EN) NOVEL NON-SYSTEMIC TGR5 AGONISTS
(FR) NOUVEAUX AGONISTES DE TGR5 NON SYSTÉMIQUES
Abstract: front page image
(EN)The present invention relates to sulfonamide compounds of formula (I) and formula (II), or a pharmaceutically acceptable salt thereof. The present sulfonamide compounds are useful non-systemic TGR5 agonists that can be used to treat diabetic diseases in human. The present invention provides a pharmaceutical composition containing sulfonamide compounds of formula (I) and formula (II) and a method of making as well as a method of using same in treating patients inflicted with metabolic disorders by administering same. The compounds of the present invention may be used in combination with additional anti-diabetic drugs.
(FR)La présente invention concerne des composés de sulfonamide de formule (I) et de formule (II), ou un sel pharmaceutiquement acceptable de ceux-ci. Ces composés de sulfonamide sont des agonistes de TGR5 non systémiques qui peuvent être utilisés pour traiter des maladies diabétiques chez l'homme. La présente invention concerne une composition pharmaceutique contenant des composés de sulfonamide de formule (I) de formule (II), ainsi qu'un procédé de fabrication et un procédé d'utilisation de celle-ci dans le traitement de patients souffrant de troubles métaboliques, par administration de celle-ci. Les composés de la présente invention peuvent être utilisés en combinaison avec des médicaments antidiabétiques additionnels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)