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1. (WO2018005801) NOVEL NON-SYSTEMIC TGR5 AGONISTS

Pub. No.:    WO/2018/005801    International Application No.:    PCT/US2017/040010
Publication Date: Fri Jan 05 00:59:59 CET 2018 International Filing Date: Fri Jun 30 01:59:59 CEST 2017
IPC: C07F 7/18
C07D 233/74
Applicants: VENENUM BIODESIGN LLC
Inventors: HUANG, Chia-Yu
SHI, Dongchuan
KULTGEN, Steven G.
MCGUINNESS, Brian F
STEIN, Philip D.
LETOURNEAU, Jeffrey J.
COLE, Andrew G.
BEASLEY, James R.
Title: NOVEL NON-SYSTEMIC TGR5 AGONISTS
Abstract:
The present invention relates to sulfonamide compounds of formula (I) and formula (II), or a pharmaceutically acceptable salt thereof. The present sulfonamide compounds are useful non-systemic TGR5 agonists that can be used to treat diabetic diseases in human. The present invention provides a pharmaceutical composition containing sulfonamide compounds of formula (I) and formula (II) and a method of making as well as a method of using same in treating patients inflicted with metabolic disorders by administering same. The compounds of the present invention may be used in combination with additional anti-diabetic drugs.