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|1. (WO2018005801) NOVEL NON-SYSTEMIC TGR5 AGONISTS|
|Applicants:||VENENUM BIODESIGN LLC
KULTGEN, Steven G.
MCGUINNESS, Brian F
STEIN, Philip D.
LETOURNEAU, Jeffrey J.
COLE, Andrew G.
BEASLEY, James R.
|Title:||NOVEL NON-SYSTEMIC TGR5 AGONISTS|
The present invention relates to sulfonamide compounds of formula (I) and formula (II), or a pharmaceutically acceptable salt thereof. The present sulfonamide compounds are useful non-systemic TGR5 agonists that can be used to treat diabetic diseases in human. The present invention provides a pharmaceutical composition containing sulfonamide compounds of formula (I) and formula (II) and a method of making as well as a method of using same in treating patients inflicted with metabolic disorders by administering same. The compounds of the present invention may be used in combination with additional anti-diabetic drugs.