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1. (WO2018005793) METHODS FOR GENERATING A GLUCOSE PERMEASE LIBRARY AND USES THEREOF
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Pub. No.: WO/2018/005793 International Application No.: PCT/US2017/039997
Publication Date: 04.01.2018 International Filing Date: 29.06.2017
IPC:
C12N 15/70 (2006.01) ,C12P 19/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70
Vectors or expression systems specially adapted for E. coli
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
02
Monosaccharides
Applicants:
ZYMERGEN INC. [US/US]; 5980 Horton Street Suite 105 Emeryville, CA 94608, US
Inventors:
MANCHESTER, Shawn; US
MELLIN, Jeffrey; US
Agent:
HOLLY, David C.; US
MCEVOY, Michael; US
VEITENHEIMER, Erich E.; US
Priority Data:
62/356,92430.06.2016US
Title (EN) METHODS FOR GENERATING A GLUCOSE PERMEASE LIBRARY AND USES THEREOF
(FR) PROCÉDÉS DE PRODUCTION D'UNE BANQUE DE GLUCOSE PERMÉASE ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) The present disclosure describes methods for generating microbial strains expressing a heterologous bacterial glucose permease gene that produce biomolecules of interest. In aspects, the disclosure provides novel bacterial strains, which express a heterologous bacterial glucose permease gene whose expression is controlled by a native Corynebacterium glutamicum promoter or a mutant promoter derived therefrom. Also provided herein are methods for producing a library of bacterial glucose permease genes using a promoter ladder comprising a plurality of promoters derived from Corynebacterium glutamicum.
(FR) La présente invention concerne des procédés de production de souches microbiennes exprimant un gène de glucose perméase hétérologue bactérien qui produisent des biomolécules d'intérêt. Dans certains aspects, l'invention concerne de nouvelles souches bactériennes, qui expriment un gène de glucose perméase hétérologue bactérien dont l'expression est régulée par un promoteur natif de Corynebacterium glutamicum ou un promoteur mutant dérivé de celui-ci. L'invention concerne également des procédés de production d'une banque de gènes de glucose perméase bactériens au moyen d'une échelle de promoteurs comprenant une pluralité de promoteurs dérivés de Corynebacterium glutamicum.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)